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When grown in an arginine medium, on the other hand, there were only a few intracellular metabolites for which their concentrations were significantly changed comparing the gdh3 / gdh3 and wild-type cells, suggesting that the gdh3 / gdh3 mutant cells were in a similar metabolic state to the wild-type cells under this environmental condition (Fig

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A deficiency in Gclc (encoding a glutamate cysteine ligase) affects major metabolic regulators, such as mTOR, NFAT, and c-Myc