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Unlike homeostatic IEC shedding where barrier integrity is maintained by rapid basolateral tight-junction protein redistribution and zipper-like replacement by neighboring cells (246, 247), necroptosis, in which several nearby IECs lose contact, has been documented to accompany TNF--induced shedding (243, 248)

"CCarnitine Homeostasis, Mitochondrial Function, and Cardiovascular Disease"

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These findings implicate MET as a therapeutic target, with strategies like MET agonists or microbiota-based interventions (to modulate gut-brain axis signaling) offering potential benefits