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In more detail, the FKBP12-rapamycin complex binds to the FRB domain of mTORC1 to produce steric hindrance, which interferes with interactions between the substrate and the active site of mTORC1 [15, 16]

Comp Biochem Physiol 149C:8389 Sole M, Anto M, Baena M, Carrasson M, Cartes JE, Maynou F (2010) Hepatic biomarkers of xenobiotic metabolism in eighteen marine fish from the NW Mediterranean slope waters in relation to some of their biological and ecological variables

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