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The five most upregulated genes in astrocytes were HMGB1, HSPH1, PTGES3, SLC7A11 and HSPA4L, while the five most downregulated genes were ANGPTL4, ETNPPL, SLC4A4, SLC6A11 and LINC00499 (Fig
Additionally, glutathione participates in the regeneration of other key antioxidants, including vitamins C and E, ensuring a comprehensive defense against oxidative damage
The excessive iron load may lead to ferroptosis in cancer patients [60,61,62], membrane transferrin receptor 1 (TFR1) can transport Fe 3+ ions into cells [63], was also recently identified as a biomarker for ferroptosis [63]