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In this study, we elucidate the inhibition mechanism of these inhibitors by crystal structure determination of TyrBm with bound KA and HQ in the active site, along with biochemical characterizations, binding constants determination and molecular modeling

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32-34 Acute toxicities arise from sudden exposures to substantial quantities of some metals (such as from occupational exposure to aluminum dust or breaking a mercury-containing thermometer) and typically affect multiple organ systems, commonly the gastrointestinal tract, cardiovascular system, nervous system, endocrine system, kidneys, hair, and nails