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Lubiprostone in constipation: clinical evidence and place in therapy

While hyperkalaemia occurred more frequently with finerenone than with placebo, this was often mild or moderate and resulted in few drug discontinuations (2.3% vs 0.9%, respectively), despite study participants also being on maximum-tolerated RAS inhibitor therapy

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According to the Summary of Product Characteristics (SmPC) approved by the MHRA, nausea is very common (may affect more than 1 in 10 people), whilst vomiting, diarrhoea, abdominal pain, and constipation are common (may affect up to 1 in 10 people)