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Researchers are encouraged to identify whether the subclinical deficiency or deficiency itself of this vitamin is a risk factor for COVID-19 complications, and it is necessary to carry out intervention studies with vitamin B 12 supplementation in both the adjuvant treatment of mild, moderate, and severe COVID-19 and postCOVID-19, with a focus on minimizing symptoms related to the musclegutbrain axis

While no further (pre)clinical interventions with NAD + modulators have been reported for this condition 263,264 , a Singaporean cohort study showed lower concentrations of circulating trigonelline, the N-methylated form of NA, in sarcopenic subjects 124

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