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There is an increased risk of reactivating latent TB infection with the use of TNF inhibitors due to the central role TNF has in maintaining TB in its latent phase due to granuloma formation ( Mycobacterium tuberculosis during latent TB infection ( There is an increased risk of various forms of candidiasis (oropharyngeal, esophageal, and cutaneous) with IL-17 inhibitors due to the involvement of IL-17 in anti- Candida host defenses ( Pregnancy and biologic treatment Overall, caution should be taken during treatment with biologics throughout pregnancy, with more data needed for many biologic treatments

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Wegovy (semaglutide) European Public Assessment Report