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Acknowledgements We are grateful to Shinji Sakai, Shinji Deguchi, Kana Furukawa for animal care

Mahima Gulati, Email: [email protected]

How Your Choice Impacts Study Design and Data Integrity Let's move from the theoretical to the practical

Weight reduction that is substantial (14 %) and rapid (over 34 months) is associated with significant bone loss [67], while more moderate and slower weight reduction may better preserve bone mass [68]