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They include (1) activation of GSH biosynthesis via supplementation of substrates and energy, (2) increased enzymatic potential to produce GSH and reduce GSSG, (3) increased activities of detoxification enzymes that use GSH, and (4) activation of routes for extrusion of GSSG and glutathione S -conjugates from cells

Secondary outcomes included changes in body weight

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This is a strategy which is differentiated by construction, differentiated by how people can approach it, he said