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However, during the progression of CAVD, qVICs undergo phenotypic changes, transitioning first into activated myofibroblasts and later into osteoblastic-like cells 35

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It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase

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The firm's failure to detect hundreds of modifications over a three-year period indicates a "Rubber Stamp" review process

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