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Supporting this model, transcriptomic analysis of 3xTg-AD mice at different disease stages (2, 10, and 20 months) revealed age-related increases in DAM-associated genes such as Trem2, Tyrobp, Clec7a , and Cd68 , particularly in aged AD mice compared to young AD mice and aged-wild-type controls (Lambracht-Washington et al., 2023)

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Regulatory status: unapproved and research-use-only As of the preparation of this article, BPC-157 has not received marketing authorization from the US Food and Drug Administration, the European Medicines Agency, or equivalent national regulators for any therapeutic indication