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4.4 Future perspectives: from mechanistic insight to clinical translation To fully harness the therapeutic potential of ferroptosis in kidney diseases, future research must address the aforementioned challenges through a combination of mechanistic depth, technological innovation, and clinical validation

Release of endogenous Zn2+ from brain tissue during activity

415 Antidepressants target astrocytes Antidepressant drugs include (i) selective serotonin reuptake inhibitors (SSRI), of which fluoxetine (Prozac) is the most popular, (ii) serotonin/noradrenaline reuptake inhibitors (SNRI), (iii) tricyclic antidepressants, (iv) inhibitors of monoaminoxidase, (v) lithium, and (vi) ketamine