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Pigmentation lightening for melanin-based dark circles requires 8-12 weeks minimum as brightening peptides and niacinamide gradually inhibit melanin production and promote hyperpigmented cell turnover

J Environ Pathol Toxicol Oncol (2018) 37(2):93101

While these injections are generally well tolerated, there are certain gastrointestinal side effects that may occur, such as vomiting, diarrhea, and nausea