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Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control

The mechanism is well-characterized in rodent models but not confirmed at the tissue level in human injectable studies for musculoskeletal indications

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The administration of the gamma subtype of peroxisome proliferator-activated receptors (PPAR) ligands has been demonstrated to reduce the production of inflammatory cytokines, such as IL-1 and TNF-, as well as inhibit the proliferation of inflammatory cells and the expression of specific adhesion molecules (305)