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b , Immunoblot analysis of indicated proteins from SLC33A1 -knockout HEK293T cells expressing a vector control or inducible ER-GshF treated with 1 g/ml doxycycline for 36 h

In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion