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The study identified five significant disproportionality signals in the system organ class (SOC) categories: gastrointestinal disorders, investigations, metabolism, nutrition disorders, neoplasms, benign/malignant, and hepatobiliary disorders

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S., & Rosene, J

Yet, the efficiency of such interventions is, in many cases, limited, and additional, second-line treatments are frequently implemented, that mainly involve the use of metformin, as insulin-sensitizer, with variable efficacy in terms of improvement of reproductive and metabolic alterations