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Additionally, the speed of semaglutide-induced weight loss often 1-2 pounds per week doesnt allow sufficient time for gradual skin remodeling that might occur with slower weight reduction

Cleveland Clinic explains that muscle tissue is metabolically active, meaning it requires more energy to maintain than fat tissue. When muscle mass decreases, resting energy expenditure may also decrease. Strength training provides a mechanical stimulus that signals the body to preserve muscle tissue during periods of reduced energy intake

Effect of bariatric surgery on systemic and adipose tissue inflammation

Patients taking SGLT2 inhibitors alongside tirzepatide should be particularly vigilant for signs of euglycaemic diabetic ketoacidosis, which can occur even when blood glucose levels are not markedly elevated