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They are not yet approved for treating people who have MASLD or MASH, but as the number of people with MASLD and MASH continues to rise, its important to find effective treatments for these chronic liver conditions

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However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]