this number is expected to rise to 12.1% by 2025, representing a 44% increase.4 If not treated properly, complications such as retinopathy, neuropathy, and nephropathy may occur, as well as increased risks for cardiovascular disease.4 If overweight, weight loss of approximately 5% of an individual's existing body weight may reduce the risk of progression from pre-diabetes to T2DM, thus demonstrating a correlation of T2DM with obesity.4 Treatments for each condition often overlap with the other, as this Clinical Pearl will demonstrate
However, repeated treatments can maximize results, and maintain the improvements
Half-Life Extension Strategies Apart from DPP-4 enzymolysis, another GLP-1/GIP degradation pathway, renal metabolism, can be overcome by augmenting the drug volume to prolong the half-life
Sanz Rodriguez T, Garca Gimnez D, de la Puerta Vzquez R