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Semaglutide activates GLP-1 receptors in the pancreas, gut, and hypothalamus to reduce appetite, slow gastric emptying, and improve glycemic control

Newly synthesized proteins targeted to lysosomes can be transported either directly into the lysosome through the trans-Golgi network depending on receptors, including mannose-6-phosphate receptor, sortilin, and lysosomal integral membrane protein type 2 87,88 , or indirectly ingested into the lumen by endocytosis 89

Funding This study was funded by the National Natural Science Foundation of China (No