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Notably, Zdhhc7 KO mice exhibited significant hyperglycemia and glucose intolerance phenotypes, a finding that not only confirms the central role of the ZDHHC7-Glut4 pathway in glucose metabolism regulation but also suggests that the defective palmitoylation of Glut4 may be an important link in the pathogenesis of diabetic hyperglycemia (232)
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Ex vivo , GSSG concentration can increase due to continued reduction of hydrogen peroxide by glutathione peroxidase and reaction with other reactive species
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