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This reflects a desire for clear dose-to-volume relationships in metabolic studies

a patients were taught to self inject b we could buy injectable B12 OTC This paper from 1983 focuses on pernicious anaemia rather than the many other causes of B12 deficiency, much like today, patients who do not have a definitive diagnosis of PA are considered to be in need of less treatment (or none at all) despite the severity of symptoms being exactly the same

This delivery route bypasses the digestive tract, preventing stomach acids and enzymes from breaking down the peptides before they can be used

B12 is one essential piece in that picture