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However, high doses may not provide extra benefits and should be avoided

Excessive ROS could lead to the depolarization of IMM, the opening of mitochondrial permeability transition pore (mPTP), and the leakage of cytochrome c (Cytc) into the cytoplasm

In addition to movement disorder, different non-motor symptoms such as dementia, psychosis and depression are observed in patients, which increase in late stages of disease

These observations with FACS analysis were confirmed by CLSM imaging, which showed clear PPIX fluorescence in the bacteria after each light exposure and the disappearance of this signal after some time (Fig