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To study the effect of these fusion proteins under oxidative stress conditions, mammalian cell lines (HeLa, PC12) were transduced with purified fusion Tat-CAT and 9Arg-CAT protein and these cells were exposed to hydrogen peroxide

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Lipogenesis in the liver and lipolysis of the adipose tissue result in elevated circulating FFA and their metabolites which can induce inflammatory responses

It is possible that the obesity phenotype in LepRb TB/TB mice is so robust that physiological changes due to restored LepRb signaling in PPG neurons alone may be obscured in these mice