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The antioxidant characteristic of N-acetylcysteine has been ascribable to its reactivity with OH, CO 3 , NO 2 , and thiyl radicals, the ability to repair oxidative damaged key cellular molecules, and activity as a precursor for biosynthesis of glutathione

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Combined with our trafficking and insulin release results, these data show a canonical role for -arrestin recruitment in promoting GLP-1R endocytosis and desensitization