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24 In this study, we further demonstrated that macrophage-derived LCN2 contributes to METH-induced PASMC proliferation, highlighting its potential as a therapeutic target for METH-PAH in humans

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In mature adipocytes, noradrenaline (NE) released by the sympathetic nervous system binds to 3-adrenergic receptors, activating the guanine nucleotide-binding protein (Gs), which in turn stimulates adenylate cyclase (AC)