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The meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P)

Those consuming high fat, high volume meals while on tirzepatide typically experience more severe gastrointestinal symptoms than those adjusting to smaller, more frequent, lower fat meals

When Cochrane reviewers grade an evidence base as very low quality despite a positive pooled effect, this is usually what they are reacting to: not that the benefit is fake, but that the conditions under which it was measured are the conditions that reliably make benefits look bigger than they are

Light stomach or empty stomach is ideal, especially in the morning