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*Correspondence: Andreas Stengel [email protected] This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Maintenance dosing schedules: Weekly injections for the first few months Bi-weekly or monthly injections after that Adjusting Frequency Based on Clinical Response The B12 injection schedule might need to change based on how well the treatment works

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However, NAD+ levels naturally decline with age, dropping by as much as 65% between age 30 and 70