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Critical analysis, research gaps, and future directions The existing body of research highlights the potential of both exercise and polyphenol supplementation in alleviating depressive symptoms and enhancing cognitive function

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Search terms included GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search included preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major cardiovascular outcome trials (CVOTs)