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Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non-alcoholic fatty liver disease assessed by magnetic resonance imaging

and millions more are expected to use them in the future (30M or roughly 9% of the population will be using GLP-1s by the year 2030, according to forecasts)

Furthermore, impaired leptin regulation in the liver disrupts satiety signals, leading to overeating and creating a vicious cycle

The regulators determined that there was no increased risk of suicidal ideation or behavior actions linked to the use of the weight loss and diabetes medications