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Previous studies in mice have reported that matched, unbiased agonists are less effective at controlling glucose and body weight than GLP-1RAs with bias similar to that of tirzepatide [35, 36]

What remains intriguing is this: after so many hard lessons learned from building around GLP-1 (the peptide of the decade) many founders still don't recognize that healthcare demands certain non-negotiable considerations: technology, regulation, and clinical expertise