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10.1016/S2213-8587(13)70152-9 104 PreissD.WelshP.SattarN

Exenatide worsens depression and causes suicidal ideation relapse: a case report

At the same time, dietary Zn deficiency in overfed animals resulted in a significant increase in serum leptin levels, being accompanied by a more intensive macrophage infiltration as compared to the HFD-Zn-adequate group [82]

In adults, single doses above 10 grams or 150 mg/kg have a reasonable likelihood of causing toxicity.[34] Toxicity can also occur when multiple smaller doses within 24 hours exceeds these levels, or even with chronic ingestion of doses as low as 4 g/day, and death with as little as 6 g/day