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Consequently, it is of major clinical significance to develop a biomaterial capable of inhibiting ferroptosis and inflammation of degenerative NPCs via reducing excessive ROS accumulation in the microenvironment, thereby restoring NPC viability and ECM homeostasis to promote disc repair, which would perform promising therapeutic efficacy on IDD

Side Effect Update for GLP-1 Receptor Agonists The FDA is requiring that Glucagon-like peptide-1 (GLP-1) drug labels include updated warnings about the risk of serious kidney injury associated with the drugs gastrointestinal effects

JAMA 299 , 10361045 (2008)

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