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Thus, whilst the CVOTs provide valuable and supportive evidence of a benefit of GLP-1 RAs on HF in people with type 2 diabetes, additional trials are required to fully understand the magnitude and nature of such a potential effect, including if it applies to both prevention and treatment of the condition

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The PK stability profile in mice of our early fusions such as Ab#2_GLP1 and Ab#2_EX4 demonstrated that the in vivo GLP-1R activity of such peptide-antibody fusion molecules rapidly decreased over time due to peptide degradation compared to the exposure achieved by the antibody Fc component (Fig

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