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Blood samples were collected from day 1 ante injectionem until day 14 post injectionem (pi) , with frequent sampling through an indwelling venous catheter from 0.5 h pi to 12 h pi

reported a patient with a homozygous LOF MC4R variant (p.Arg165Gln) who initially lost 40 kg following Roux-en-Y gastric bypass but subsequently regained all lost weight [68]