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Journal of Clinical Epidemiology , 47(9), 10211026

[2] Antioxidant enzymes, such as glutathione peroxidases and peroxiredoxins, generate glutathione disulfide during the reduction of peroxides such as hydrogen peroxide (H 2 O 2 ) and organic hydroperoxides (ROOH): [3] 2 GSH + ROOH GSSG + ROH + H 2 O Other enzymes, such as glutaredoxins, generate glutathione disulfide through thiol-disulfide exchange with protein disulfide bonds or other low molecular mass compounds, such as coenzyme A disulfide or dehydroascorbic acid

Environmental pollutants, sun exposure, poor diet, chronic stress, smoking, and lack of sleep all contribute to oxidative stress, speeding up skin damage and aging

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