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These benefits have been demonstrated in large, well-designed cardiovascular outcome trials, including: Liraglutide (Victoza) the LEADER trial , which showed a significant reduction in cardiovascular death and all-cause mortality Semaglutide (Ozempic) the SUSTAIN-6 trial , demonstrating fewer major adverse cardiovascular events, particularly stroke Dulaglutide (Trulicity) the REWIND trial , which showed a significant reduction in major cardiovascular events even in people without established cardiovascular disease Tirzepatide (Mounjaro) cardiovascular outcome data from the SURPASS-CVOT programme are emerging, with early results suggesting cardiovascular benefit compared with insulin therapy These cardiovascular effects are a key reason why GLP-1based therapies are now recommended earlier in the treatment pathway for people with type 2 diabetes who have established heart disease or are at high cardiovascular risk

GLP-1 receptor agonists have been extensively studied in large-scale clinical trials

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But the best outcomes come from pairing the medication with: A plan you can actually follow A strategy for side effects A maintenance plan for the long haul And a serious commitment to protecting muscle with protein and strength training If youre thinking about starting, the most important question is not Which drug is best? Its: What is the safest plan that I can sustain, and how are we supporting my future self? References (APA) Aronne, L