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In dysbiosis, altered sialidase activity might expose more or fewer Siglec-8 ligands

Seino Y, Terauchi Y, Osonoi T, Yabe D, Abe N, Nishida T, Zacho J, Kaneko S

Published Phase 3 efficacy-estimand data shows retatrutide at 12 mg producing about 28.7% weight loss over 68 weeks (TRIUMPH-4) versus orforglipron at 36 mg producing about 12.4% over 72 weeks (ATTAIN-1)