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Tirzepatide is a dual GIP/GLP-1 receptor agonist, meaning it activates two incretin receptors simultaneously

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M., Leech, J., Murphy, C., DeBros, G., Budson, A., & Solomon, P

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Therefore, they might not be MDR1 substrates, thus avoiding MDR1-mediated drug resistance

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Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys

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