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CaMKK2 increases the activity of each effector target by phosphorylating a highly-conserved threonine residue located within the regulatory activation loops of each of their kinase domains [51]

"LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept." Molecular Metabolism , 18, 3-14

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For example, MT2's impact on feeding behavior and central nervous system activity opens doors to its use in managing disorders such as obesity and addiction