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This randomized, double-blind, parallel-group, placebo-controlled, forced-dose titration study (Study 10) consisted of an 11-week double-blind treatment period (3 weeks of forced-dose titration followed by 8 weeks of dose maintenance)

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Our mass spectrometry analysis of low molecular weight lipids from ESA-treated cells revealed the formation of two distinct adducts of di-oxygenated ESA free fatty acid with DAG containing two ESA-derived chains (Fig