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Most patients begin noticing reduced appetite and increased fullness within 3-7 days of starting oral tirzepatide, though measurable weight loss typically becomes apparent within 2-4 weeks as appetite suppression compounds into consistent calorie reduction

Reviewers, including the Indian Journal of Dermatology, Venereology and Leprology paper on this exact topic, note that how long brightening lasts after stopping hasn't been properly studied yet treat it as maintenance, not a one-time fix