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Oral d 9 -carnitine challenge test in the mouse On the day of the sacrifice, the mice were gavaged with 200 L (150 mM) of d 9 -carnitine, followed by serial blood collection at 0, 4, 8, and 10 h 40

Results Loss of IRE1 dictates resistance to ferroptosis induction Although earlier studies identified that certain ferroptosis inducers (FINs) activate the eIF2-ATF4 signaling axis by interacting with the UPR, defining the role of the UPR in regulating ferroptosis has been elusive 9

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