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Ozempic, Mounjaro, and Rybelsus are FDA-approved diabetes medications that are covered only for patients who have type 2 diabetes
Though the trial was powered to only detect non-inferiority, the observed (non-significant) hazard ratio for semaglutide vs
Some analyses also suggest an increased risk of biliary disease, particularly cholelithiasis, with GLP-1RA therapy
Certain GLP-1 formulations have demonstrated cardiovascular benefits in clinical trials, leading to specific FDA approvals: Victoza, Ozempic, and Trulicity are approved for reducing major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease, while Wegovy is approved for cardiovascular risk reduction in adults with established cardiovascular disease and either obesity or overweight
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