The cloned human GS promoter contains two regions with homology to the NFE2 (nuclear factor erythroid 2) motif that are required for basal activity as mutation of these sites reduced the human GS promoter activity by 66% (Lee et al., 2005)
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Risk factors that increase this concern include: History of peptic ulcer disease or gastrointestinal bleeding Concurrent use of anticoagulants (warfarin, apixaban) or antiplatelet agents (aspirin, clopidogrel) Use of corticosteroids or selective serotonin reuptake inhibitors (SSRIs) Chronic alcohol consumption Presence of Helicobacter pylori infection For patients taking low-dose aspirin for cardiovascular protection, ibuprofen can interfere with aspirin's antiplatelet effect
[DOI] [PubMed] [Google Scholar] 77.Killion EA, Chen M, Falsey JR, Sivits G, Hager T, Atangan L, Helmering J, Lee J, Li H, Wu B, et al