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In musculoskeletal research models, it has been associated with altered fibroblast behavior and extracellular matrix organization

However, GLP-1 receptor agonists are not recommended if you: - Are pregnant - Are hypersensitive to GLP-1 - Have severe gastrointestinal conditions like inflammatory bowel disease (IBD) - Are at a higher risk of certain thyroid cancers If you have a history of pancreatitis, kidney failure, or gallbladder disease, GLP-1 receptor agonists may not be safe for you

In addition, impaired cell membrane fluidity, inflammatory responses and change of hepatocyte tight junctions are also involved in the pathogenesis of EIC

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