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The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)
In this system, the MOF@COF nanocapsule utilizes - stacking interactions to efficiently load the hydrophobic drug niraparib and ensure its controlled release
Additionally, patients with a known hypersensitivity to semaglutide or any of its components should avoid using the medication
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