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Gene expression profiles in the liver and kidney of metallothionein-null mice

Ushio-Fukai M, Ash D, Nagarkoti S, Belin De Chantemle EJ, Fulton DJR, Fukai T

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To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations