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Contraindications GHK-Cu peptide therapy may not be suitable for individuals who: Have known hypersensitivity to copper peptides Are pregnant or breastfeeding without medical clearance Have active skin infections at the application or injection site A consultation is required to determine suitability

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Additional IDA criteria included selection of ions above 400 m/z with intensities exceeding 10 6 counts, and dynamic exclusion of previously selected target ions for 30 s after 2 occurrences

The refined models exhibited good model-density fitting and model geometry (see Supplementary information, Table S1 for data and model refinement statistics)